arachidonate 5-lipoxygenase

Symbol

Alox5

Organism

Mouse

Orthologs

SymbolSpecies
zgc:110251 Danio rerio
ALOX5 Homo sapiens
Alox5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1969 Alox5 arachidonate 5-lipoxygenase (5-LOX) mRNA expression decrease Molecular heart Mouse Alox5 —
DAA1965 Alox5 arachidonate 5-lipoxygenase (5-LOX) mRNA expression increase Molecular heart Mouse Alox5 —
DAA1963 Alox5 arachidonate 5-lipoxygenase (5-LOX) promoter methylation increase Molecular heart Mouse Alox5 —
DAA1964 Alox5 arachidonate 5-lipoxygenase (5-LOX) promoter methylation increase Molecular cerebellum Mouse Alox5 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2987 Gene expression of ALOX5 increases with age Molecular skin Human ALOX5 —

GO Terms

GO IDGO TermGO Category
GO:0002526 acute inflammatory response biological_process
GO:0002540 leukotriene production involved in inflammatory response biological_process
GO:0006691 leukotriene metabolic process biological_process
GO:0006954 inflammatory response biological_process
GO:0019233 sensory perception of pain biological_process
GO:0019369 arachidonic acid metabolic process biological_process
GO:0019370 leukotriene biosynthetic process biological_process
GO:0019372 lipoxygenase pathway biological_process
GO:0045907 positive regulation of vasoconstriction biological_process
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005635 nuclear envelope cellular_component
GO:0005641 nuclear envelope lumen cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0016020 membrane cellular_component
GO:0016363 nuclear matrix cellular_component
GO:0030425 dendrite cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0042383 sarcolemma cellular_component
GO:0004051 arachidonate 5-lipoxygenase activity molecular_function
GO:0005506 iron ion binding molecular_function
GO:0016165 lipoxygenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular_function
GO:0046872 metal ion binding molecular_function