autophagy related 4A, cysteine peptidase


ATG4A (may also be known as: None)




Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008]


Atg4 Drosophila melanogaster
atg4a Danio rerio
Atg4a Mus musculus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006508 proteolysis biological_process
GO:0006914 autophagy biological_process
GO:0015031 protein transport biological_process
GO:0005737 cytoplasm cellular_component
GO:0008233 peptidase activity molecular_function
GO:0008234 cysteine-type peptidase activity molecular_function