cholinergic receptor, nicotinic, epsilon (muscle)

Symbol

CHRNE (may also be known as: None)

Organism

Human

Description

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]

Orthologs

SymbolSpecies
chrne Danio rerio
Chrne Mus musculus
Chrne Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2698 Hypomethylation of CHRNE is positively correlated with age Molecular blood Human CHRNE —

GO Terms

GO IDGO TermGO Category
GO:0006810 transport biological_process
GO:0006812 cation transport biological_process
GO:0006936 muscle contraction biological_process
GO:0007165 signal transduction biological_process
GO:0007268 synaptic transmission biological_process
GO:0007271 synaptic transmission, cholinergic biological_process
GO:0042391 regulation of membrane potential biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0005892 acetylcholine-gated channel complex cellular_component
GO:0030054 cell junction cellular_component
GO:0045202 synapse cellular_component
GO:0045211 postsynaptic membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0004889 acetylcholine-activated cation-selective channel activity molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005230 extracellular ligand-gated ion channel activity molecular_function
GO:0008324 cation transmembrane transporter activity molecular_function
GO:0015464 acetylcholine receptor activity molecular_function