hypoxia up-regulated 1

Symbol

HYOU1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Orthologs

SymbolSpecies
CELE_T24H7.2 Caenorhabditis elegans
EG:25E8.1 Drosophila melanogaster
hyou1 Danio rerio
Hyou1 Mus musculus
Hyou1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001666 response to hypoxia biological_process
GO:0006950 response to stress biological_process
GO:0006987 activation of signaling protein activity involved in unfolded protein response biological_process
GO:0030968 endoplasmic reticulum unfolded protein response biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005788 endoplasmic reticulum lumen cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005524 ATP binding molecular_function