adenosine deaminase, RNA-specific, B1

Symbol

ADARB1 (may also be known as: None)

Organism

Human

Description

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
adarb1a Danio rerio
Adarb1 Mus musculus
Adarb1 Rattus norvegicus
TAD1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006382 adenosine to inosine editing biological_process
GO:0006396 RNA processing biological_process
GO:0006397 mRNA processing biological_process
GO:0010467 gene expression biological_process
GO:0016553 base conversion or substitution editing biological_process
GO:0016556 mRNA modification biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0003723 RNA binding molecular_function
GO:0003725 double-stranded RNA binding molecular_function
GO:0003726 double-stranded RNA adenosine deaminase activity molecular_function
GO:0003729 mRNA binding molecular_function
GO:0004000 adenosine deaminase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0046872 metal ion binding molecular_function