ATP-binding cassette, sub-family A (ABC1), member 8
Symbol
ABCA8
(may also be known as: None)
Organism
Human
Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Abca8b | Mus musculus | |
| Abca8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2393 | ATP-binding cassette; sub-family A member 8 decreases with age | Molecular | dermis | Human | ABCA8 | 23.4% Decrease DNA Methylation | |
| DAA2442 | ATP-binding cassette; sub-family A member 8 decreases with age | Molecular | mesenchymal stem cell | Human | ABCA8 | 25.0% Decrease DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006810 | transport | biological_process | |
| GO:0055085 | transmembrane transport | biological_process | |
| GO:0005743 | mitochondrial inner membrane | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016887 | ATPase activity | molecular_function | |
| GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | molecular_function | |