A kinase (PRKA) anchor protein 8
Symbol
AKAP8
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| Akap8 | Mus musculus | |
| Akap8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007067 | mitosis | biological_process | |
| GO:0007076 | mitotic chromosome condensation | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0000793 | condensed chromosome | cellular_component | |
| GO:0001939 | female pronucleus | cellular_component | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0016363 | nuclear matrix | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003690 | double-stranded DNA binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0016301 | kinase activity | molecular_function | |
| GO:0034237 | protein kinase A regulatory subunit binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |