sprouty homolog 2 (Drosophila)

Symbol

SPRY2 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
spry2 Danio rerio
Spry2 Mus musculus
Spry2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3606 Gene expression of SPRY2 increases with age Molecular skin Human SPRY2 —

GO Terms

GO IDGO TermGO Category
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007605 sensory perception of sound biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0009966 regulation of signal transduction biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0033138 positive regulation of peptidyl-serine phosphorylation biological_process
GO:0034261 negative regulation of Ras GTPase activity biological_process
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway biological_process
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway biological_process
GO:0042472 inner ear morphogenesis biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043407 negative regulation of MAP kinase activity biological_process
GO:0045165 cell fate commitment biological_process
GO:0046580 negative regulation of Ras protein signal transduction biological_process
GO:0048754 branching morphogenesis of a tube biological_process
GO:0051387 negative regulation of nerve growth factor receptor signaling pathway biological_process
GO:0051897 positive regulation of protein kinase B signaling cascade biological_process
GO:0060425 lung morphogenesis biological_process
GO:0060437 lung growth biological_process
GO:0070373 negative regulation of ERK1 and ERK2 cascade biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0071902 positive regulation of protein serine/threonine kinase activity biological_process
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005874 microtubule cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0032587 ruffle membrane cellular_component
GO:0042995 cell projection cellular_component
GO:0005515 protein binding molecular_function
GO:0043539 protein serine/threonine kinase activator activity molecular_function