Epstein-Barr virus induced 3


EBI3 (may also be known as: None)




This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]


ebi3 Danio rerio
Ebi3 Mus musculus
Ebi3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1306 Epstein-Barr virus induced gene 3 Molecular hematological system Mouse Ebi3 27.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006959 humoral immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0042088 T-helper 1 type immune response biological_process
GO:0045078 positive regulation of interferon-gamma biosynthetic process biological_process
GO:0046641 positive regulation of alpha-beta T cell proliferation biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005886 plasma membrane cellular_component
GO:0004896 cytokine receptor activity molecular_function
GO:0005125 cytokine activity molecular_function
GO:0045523 interleukin-27 receptor binding molecular_function