| SIRT1 activity negatively correlated with age in males | — | skin | Human | |
| responses to hypoxemia and hypercapnia are decreased | — | respiratory system | Human | |
| Basal oxygen uptake per kilogram of body water unchanged | — | whole body | Human | |
| cortisol levels increased | — | plasma | Human | |
| variability in clearance of hepatically metabolized drugs | — | liver | Human | |
| osteoporosis: progressive loss of bone strength | — | bone | Human | |
| decline in epidermis keratinocyte turnover | — | epidermis | Human | |
| sex hormone binding globulin levels increase | — | endocrine system | Human | |
| Attenuated vasoconstriction response to cold | — | skin | Human | |
| bone becomes more brittle, less flexible | — | bone | Human | |
| deficiencies in generating secondary peristaltic contractions | — | oropharynx, oesophagus | Human | |
| diminishing of glandular secretions | — | alimentary system | Human | |
| pro-B cell generation and differentiation declines | — | bone marrow, B cell | Human | |
| cytotoxicity and interleukin-2 response of natural killer cells decreases | — | natural killer cell | Human | |
| chondroitin sulfate molecules are smaller | — | cartilage | Human | |
| Lipid biosynthesis decreases | — | central nervous system | Human | |
| viscoelastic modulus of brain tissue decreases | — | brain | Human | |
| T-cell diversity declines | — | T cell | Human | |
| Cholesterol level - Borderline (Female) | SeriesIncidence | plasma | Human | |
| chemotaxis and respiratory burst capacity in response to GM-CSF priming decreased | — | neutrophil | Human | |
| E-rosette-forming cells decrease | — | thymus | Human | |
| Mosaic abnormalities increase | — | blood, oral cavity | Human | |
| dermal collagen atrophies | — | dermis | Human | |
| Hematopoietic cells accumulate random mutations | — | hematopoietic stem cells | Human | |
| cell proliferation increases | — | arterial intima | Human | |