| DAA954 |
Number of T cell progenitors declines |
Physiological |
T cell progenitor |
Human |
— |
— |
|
| DAA980 |
Phagocytosis activity decreased in response to opsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA981 |
Phagocytosis activity unchanged in response to unopsonized targets |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA935 |
Pro-B cell generation and differentiation declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
| DAA956 |
Proliferation is reduced |
Physiological |
lymphocytes |
Human |
— |
— |
|
| DAA977 |
ROS production in response to stimuli unchanged |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA984 |
Spontaneous production of superoxide decreased |
Physiological |
neutrophil |
Human |
— |
— |
|
| DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|
| DAA2599 |
Telomere shortening |
Physiological |
adipose tissue, skeletal muscle, skin, leukocyte |
Human |
— |
— |
|
| DAA945 |
Thymus involution |
Physiological |
thymus |
Human |
— |
— |
|
| DAA966 |
Vaccination antibody response is impaired |
Physiological |
immune system |
Human |
— |
— |
|
| DAA948 |
Volume of perivascular space around thymus increases |
Physiological |
thymus |
Human |
— |
— |
|
| DAA988 |
Function declines |
Physiological |
dendritic cell |
Mouse |
— |
— |
|
| DAA1953 |
Interleukin-6 plasma levels are elevated in response to acute systemic inflammation |
Physiological |
immune system |
Mouse |
— |
— |
|
| DAA943 |
Lower affinity antibodies generated |
Physiological |
B cell |
Mouse |
— |
— |
|
| DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
| DAA1947 |
Vitamin C levels decrease |
Physiological |
blood, T cell |
Mouse |
— |
— |
|
| DAA949 |
Cytomegalovirus infection incidence increases |
Pathological |
immune system |
Human |
— |
— |
|
| DAA2557 |
Level of miR-212 decreases with age |
Molecular |
T cell |
Human |
MIR212 |
66.0% Decrease miRNA Level |
|
| DAA2547 |
Level of miR-21 decreases with age |
Molecular |
T cell |
Human |
MIR21 |
83.6% Decrease miRNA Level |
|
| DAA2549 |
Level of miR-23a increases with age |
Molecular |
T cell |
Human |
MIR23A |
137.2% Increase miRNA Level |
|
| DAA2565 |
Level of miR-23b increases with age |
Molecular |
T cell |
Human |
MIR23B |
32.8% Increase miRNA Level |
|
| DAA2558 |
Level of miR-27a decreases with age |
Molecular |
T cell |
Human |
MIR27A |
47.7% Decrease miRNA Level |
|
| DAA2573 |
Level of miR-27b decreases with age |
Molecular |
T cell |
Human |
MIR27B |
31.7% Decrease miRNA Level |
|
| DAA2552 |
Level of miR-29b decreases with age |
Molecular |
T cell |
Human |
MIR29B1 |
57.3% Decrease miRNA Level |
|