zinc finger E-box binding homeobox 2
Symbol
ZEB2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| zag-1 | Caenorhabditis elegans | |
| zfh1 | Drosophila melanogaster | |
| zeb2b | Danio rerio | |
| Zeb2 | Mus musculus | |
| Zeb2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001755 | neural crest cell migration | biological_process | |
| GO:0001756 | somitogenesis | biological_process | |
| GO:0001843 | neural tube closure | biological_process | |
| GO:0007399 | nervous system development | biological_process | |
| GO:0007417 | central nervous system development | biological_process | |
| GO:0021766 | hippocampus development | biological_process | |
| GO:0021846 | cell proliferation in forebrain | biological_process | |
| GO:0030177 | positive regulation of Wnt receptor signaling pathway | biological_process | |
| GO:0043507 | positive regulation of JUN kinase activity | biological_process | |
| GO:0048598 | embryonic morphogenesis | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0003676 | nucleic acid binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0019208 | phosphatase regulator activity | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |
| GO:0046332 | SMAD binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |