T-box 4

Symbol

TBX4 (may also be known as: None)

Organism

Human

Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
org-1 Drosophila melanogaster
tbx4 Danio rerio
Tbx4 Mus musculus
Tbx4 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001525 angiogenesis biological_process
GO:0002009 morphogenesis of an epithelium biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0007275 multicellular organismal development biological_process
GO:0030324 lung development biological_process
GO:0030326 embryonic limb morphogenesis biological_process
GO:0035108 limb morphogenesis biological_process
GO:0048705 skeletal system morphogenesis biological_process
GO:0005634 nucleus cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function