leupaxin
Symbol
LPXN
(may also be known as: None)
Organism
Human
Description
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| pxn | Danio rerio | |
| Lpxn | Mus musculus | |
| Lpxn | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006461 | protein complex assembly | biological_process | |
| GO:0007155 | cell adhesion | biological_process | |
| GO:0007162 | negative regulation of cell adhesion | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0050859 | negative regulation of B cell receptor signaling pathway | biological_process | |
| GO:0002102 | podosome | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005925 | focal adhesion | cellular_component | |
| GO:0003712 | transcription cofactor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |