leupaxin

Symbol

LPXN (may also be known as: None)

Organism

Human

Description

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Orthologs

SymbolSpecies
pxn Danio rerio
Lpxn Mus musculus
Lpxn Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006461 protein complex assembly biological_process
GO:0007155 cell adhesion biological_process
GO:0007162 negative regulation of cell adhesion biological_process
GO:0007165 signal transduction biological_process
GO:0050859 negative regulation of B cell receptor signaling pathway biological_process
GO:0002102 podosome cellular_component
Show more GO terms