Zic family member 1

Symbol

ZIC1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
zic1 Danio rerio
Zic1 Mus musculus
Zic1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0007389 pattern specification process biological_process
GO:0007420 brain development biological_process
GO:0007610 behavior biological_process
GO:0008589 regulation of smoothened signaling pathway biological_process
GO:0021510 spinal cord development biological_process
GO:0030154 cell differentiation biological_process
GO:0042307 positive regulation of protein import into nucleus biological_process
GO:0042472 inner ear morphogenesis biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0046872 metal ion binding molecular_function