Zic family member 1

Symbol

ZIC1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
zic1	Danio rerio
Zic1	Mus musculus
Zic1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2775	Hypermethylation of ZIC1 is positively correlated with age	Molecular	blood	Human	ZIC1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006355	regulation of transcription, DNA-dependent	biological_process
GO:0007389	pattern specification process	biological_process
GO:0007420	brain development	biological_process
GO:0007610	behavior	biological_process
GO:0008589	regulation of smoothened signaling pathway	biological_process
GO:0021510	spinal cord development	biological_process
GO:0030154	cell differentiation	biological_process
GO:0042307	positive regulation of protein import into nucleus	biological_process
GO:0042472	inner ear morphogenesis	biological_process
GO:0045893	positive regulation of transcription, DNA-dependent	biological_process
GO:0005622	intracellular	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0003677	DNA binding	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular_function
GO:0008270	zinc ion binding	molecular_function
GO:0046872	metal ion binding	molecular_function
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