Zic family member 1
Symbol
ZIC1
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| zic1 | Danio rerio | |
| Zic1 | Mus musculus | |
| Zic1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0007389 | pattern specification process | biological_process | |
| GO:0007420 | brain development | biological_process | |
| GO:0007610 | behavior | biological_process | |
| GO:0008589 | regulation of smoothened signaling pathway | biological_process | |
| GO:0021510 | spinal cord development | biological_process | |
| GO:0030154 | cell differentiation | biological_process | |
| GO:0042307 | positive regulation of protein import into nucleus | biological_process | |
| GO:0042472 | inner ear morphogenesis | biological_process | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |