von Willebrand factor

Symbol

VWF (may also be known as: None)

Organism

Human

Description

The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
vwf Danio rerio
Vwf Mus musculus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2643 Hypomethylation of VWF is positively correlated with age Molecular blood Human VWF —

GO Terms

GO IDGO TermGO Category
GO:0001889 liver development biological_process
GO:0001890 placenta development biological_process
GO:0002576 platelet degranulation biological_process
GO:0007155 cell adhesion biological_process
GO:0007596 blood coagulation biological_process
GO:0007597 blood coagulation, intrinsic pathway biological_process
GO:0007599 hemostasis biological_process
GO:0009611 response to wounding biological_process
GO:0030168 platelet activation biological_process
GO:0031589 cell-substrate adhesion biological_process
GO:0051260 protein homooligomerization biological_process
GO:0005576 extracellular region cellular_component
GO:0005578 proteinaceous extracellular matrix cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0031012 extracellular matrix cellular_component
GO:0031091 platelet alpha granule cellular_component
GO:0031093 platelet alpha granule lumen cellular_component
GO:0033093 Weibel-Palade body cellular_component
GO:0001948 glycoprotein binding molecular_function
GO:0002020 protease binding molecular_function
GO:0005178 integrin binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005518 collagen binding molecular_function
GO:0019865 immunoglobulin binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0047485 protein N-terminus binding molecular_function
GO:0051087 chaperone binding molecular_function