von Willebrand factor

Symbol

VWF (may also be known as: None)

Organism

Human

Description

The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
vwf	Danio rerio
Vwf	Mus musculus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2643	Hypomethylation of VWF is positively correlated with age	Molecular	blood	Human	VWF	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001889	liver development	biological_process
GO:0001890	placenta development	biological_process
GO:0002576	platelet degranulation	biological_process
GO:0007155	cell adhesion	biological_process
GO:0007596	blood coagulation	biological_process
GO:0007597	blood coagulation, intrinsic pathway	biological_process
GO:0007599	hemostasis	biological_process
GO:0009611	response to wounding	biological_process
GO:0030168	platelet activation	biological_process
GO:0031589	cell-substrate adhesion	biological_process
GO:0051260	protein homooligomerization	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005578	proteinaceous extracellular matrix	cellular_component
GO:0005783	endoplasmic reticulum	cellular_component
GO:0009897	external side of plasma membrane	cellular_component
GO:0031012	extracellular matrix	cellular_component
GO:0031091	platelet alpha granule	cellular_component
GO:0031093	platelet alpha granule lumen	cellular_component
GO:0033093	Weibel-Palade body	cellular_component
GO:0001948	glycoprotein binding	molecular_function
GO:0002020	protease binding	molecular_function
GO:0005178	integrin binding	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005518	collagen binding	molecular_function
GO:0019865	immunoglobulin binding	molecular_function
GO:0042803	protein homodimerization activity	molecular_function
GO:0047485	protein N-terminus binding	molecular_function
GO:0051087	chaperone binding	molecular_function
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