TNF receptor-associated factor 6, E3 ubiquitin protein ligase

Symbol

TRAF6 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]

Orthologs

SymbolSpecies
CELE_Y110A7A.2 Caenorhabditis elegans
Traf6 Drosophila melanogaster
traf6 Danio rerio
Traf6 Mus musculus
Traf6 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2653 Hypomethylation of TRAF6 is positively correlated with age Molecular blood Human TRAF6 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0000209 protein polyubiquitination biological_process
GO:0001503 ossification biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002726 positive regulation of T cell cytokine production biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0006915 apoptotic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0007165 signal transduction biological_process
GO:0007249 I-kappaB kinase/NF-kappaB cascade biological_process
GO:0007250 activation of NF-kappaB-inducing kinase activity biological_process
GO:0007254 JNK cascade biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0016567 protein ubiquitination biological_process
GO:0031293 membrane protein intracellular domain proteolysis biological_process
GO:0032147 activation of protein kinase activity biological_process
GO:0032743 positive regulation of interleukin-2 production biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043507 positive regulation of JUN kinase activity biological_process
GO:0045087 innate immune response biological_process
GO:0045672 positive regulation of osteoclast differentiation biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0050870 positive regulation of T cell activation biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0051865 protein autoubiquitination biological_process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway biological_process
GO:0070534 protein K63-linked ubiquitination biological_process
GO:0070555 response to interleukin-1 biological_process
GO:2000679 positive regulation of transcription regulatory region DNA binding biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005938 cell cortex cellular_component
GO:0009898 internal side of plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0035631 CD40 receptor complex cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0004842 ubiquitin-protein ligase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0031435 mitogen-activated protein kinase kinase kinase binding molecular_function
GO:0042826 histone deacetylase binding molecular_function
GO:0043422 protein kinase B binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0047485 protein N-terminus binding molecular_function