TNF receptor-associated factor 6, E3 ubiquitin protein ligase

Symbol

TRAF6 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]

Orthologs

Symbol	Species
CELE_Y110A7A.2	Caenorhabditis elegans
Traf6	Drosophila melanogaster
traf6	Danio rerio
Traf6	Mus musculus
Traf6	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2653	Hypomethylation of TRAF6 is positively correlated with age	Molecular	blood	Human	TRAF6	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0000187	activation of MAPK activity	biological_process
GO:0000209	protein polyubiquitination	biological_process
GO:0001503	ossification	biological_process
GO:0002224	toll-like receptor signaling pathway	biological_process
GO:0002726	positive regulation of T cell cytokine production	biological_process
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological_process
GO:0006915	apoptotic process	biological_process
GO:0006916	anti-apoptosis	biological_process
GO:0007165	signal transduction	biological_process
GO:0007249	I-kappaB kinase/NF-kappaB cascade	biological_process
GO:0007250	activation of NF-kappaB-inducing kinase activity	biological_process
GO:0007254	JNK cascade	biological_process
GO:0008063	Toll signaling pathway	biological_process
GO:0008624	induction of apoptosis by extracellular signals	biological_process
GO:0016567	protein ubiquitination	biological_process
GO:0031293	membrane protein intracellular domain proteolysis	biological_process
GO:0032147	activation of protein kinase activity	biological_process
GO:0032743	positive regulation of interleukin-2 production	biological_process
GO:0034130	toll-like receptor 1 signaling pathway	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	biological_process
GO:0034138	toll-like receptor 3 signaling pathway	biological_process
GO:0034142	toll-like receptor 4 signaling pathway	biological_process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological_process
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological_process
GO:0042981	regulation of apoptotic process	biological_process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological_process
GO:0043507	positive regulation of JUN kinase activity	biological_process
GO:0045087	innate immune response	biological_process
GO:0045672	positive regulation of osteoclast differentiation	biological_process
GO:0045892	negative regulation of transcription, DNA-dependent	biological_process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_process
GO:0048011	nerve growth factor receptor signaling pathway	biological_process
GO:0050852	T cell receptor signaling pathway	biological_process
GO:0050870	positive regulation of T cell activation	biological_process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological_process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological_process
GO:0051403	stress-activated MAPK cascade	biological_process
GO:0051865	protein autoubiquitination	biological_process
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	biological_process
GO:0070534	protein K63-linked ubiquitination	biological_process
GO:0070555	response to interleukin-1	biological_process
GO:2000679	positive regulation of transcription regulatory region DNA binding	biological_process
GO:0005634	nucleus	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0005938	cell cortex	cellular_component
GO:0009898	internal side of plasma membrane	cellular_component
GO:0010008	endosome membrane	cellular_component
GO:0031965	nuclear membrane	cellular_component
GO:0035631	CD40 receptor complex	cellular_component
GO:0048471	perinuclear region of cytoplasm	cellular_component
GO:0004842	ubiquitin-protein ligase activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0008270	zinc ion binding	molecular_function
GO:0016874	ligase activity	molecular_function
GO:0019901	protein kinase binding	molecular_function
GO:0031435	mitogen-activated protein kinase kinase kinase binding	molecular_function
GO:0042826	histone deacetylase binding	molecular_function
GO:0043422	protein kinase B binding	molecular_function
GO:0046872	metal ion binding	molecular_function
GO:0047485	protein N-terminus binding	molecular_function
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