tetraspanin 8
Symbol
TSPAN8
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Tspan8 | Mus musculus | |
| Tspan8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2410 | transmembrane 4 superfamily member 3 decreases with age | Molecular | dermis | Human | TSPAN8 | 17.9% Decrease DNA Methylation | |
| DAA2459 | transmembrane 4 superfamily member 3 increases with age | Molecular | mesenchymal stem cell | Human | TSPAN8 | 36.4% Increase DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006486 | protein glycosylation | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0030195 | negative regulation of blood coagulation | biological_process | |
| GO:0005764 | lysosome | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0004871 | signal transducer activity | molecular_function | |