tetraspanin 8


TSPAN8 (may also be known as: None)




The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]


Tspan8 Mus musculus
Tspan8 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2410 transmembrane 4 superfamily member 3 decreases with age Molecular dermis Human TSPAN8 17.9% Decrease DNA Methylation
DAA2459 transmembrane 4 superfamily member 3 increases with age Molecular mesenchymal stem cell Human TSPAN8 36.4% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0006486 protein glycosylation biological_process
GO:0007165 signal transduction biological_process
GO:0030195 negative regulation of blood coagulation biological_process
GO:0005764 lysosome cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004871 signal transducer activity molecular_function