nucleotide-binding oligomerization domain containing 2

Symbol

NOD2 (may also be known as: None)

Organism

Human

Description

This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Orthologs

SymbolSpecies
nod2 Danio rerio
Nod2 Mus musculus
Nod2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2639 Hypomethylation of NOD2 is positively correlated with age Molecular blood Human NOD2 —

GO Terms

GO IDGO TermGO Category
GO:0000187 activation of MAPK activity biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002367 cytokine production involved in immune response biological_process
GO:0002606 positive regulation of dendritic cell antigen processing and presentation biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0002830 positive regulation of type 2 immune response biological_process
GO:0006952 defense response biological_process
GO:0007254 JNK cascade biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0009595 detection of biotic stimulus biological_process
GO:0016045 detection of bacterium biological_process
GO:0032495 response to muramyl dipeptide biological_process
GO:0032498 detection of muramyl dipeptide biological_process
GO:0032731 positive regulation of interleukin-1 beta production biological_process
GO:0032733 positive regulation of interleukin-10 production biological_process
GO:0032740 positive regulation of interleukin-17 production biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032760 positive regulation of tumor necrosis factor production biological_process
GO:0032874 positive regulation of stress-activated MAPK cascade biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035419 activation of MAPK activity involved in innate immune response biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0042742 defense response to bacterium biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity biological_process
GO:0045087 innate immune response biological_process
GO:0045747 positive regulation of Notch signaling pathway biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0046645 positive regulation of gamma-delta T cell activation biological_process
GO:0050679 positive regulation of epithelial cell proliferation biological_process
GO:0050718 positive regulation of interleukin-1 beta secretion biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:0050871 positive regulation of B cell activation biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051259 protein oligomerization biological_process
GO:0051353 positive regulation of oxidoreductase activity biological_process
GO:0051403 stress-activated MAPK cascade biological_process
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process biological_process
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway biological_process
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway biological_process
GO:2000110 negative regulation of macrophage apoptosis biological_process
GO:2000363 positive regulation of prostaglandin-E synthase activity biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0008180 signalosome cellular_component
GO:0009986 cell surface cellular_component
GO:0031982 vesicle cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0019899 enzyme binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0032500 muramyl dipeptide binding molecular_function
GO:0042834 peptidoglycan binding molecular_function
GO:0050700 CARD domain binding molecular_function