nucleotide-binding oligomerization domain containing 2

Symbol

NOD2 (may also be known as: None)

Organism

Human

Description

This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Orthologs

Symbol	Species
nod2	Danio rerio
Nod2	Mus musculus
Nod2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2639	Hypomethylation of NOD2 is positively correlated with age	Molecular	blood	Human	NOD2	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000187	activation of MAPK activity	biological_process
GO:0002224	toll-like receptor signaling pathway	biological_process
GO:0002367	cytokine production involved in immune response	biological_process
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	biological_process
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological_process
GO:0002830	positive regulation of type 2 immune response	biological_process
GO:0006952	defense response	biological_process
GO:0007254	JNK cascade	biological_process
GO:0008063	Toll signaling pathway	biological_process
GO:0009595	detection of biotic stimulus	biological_process
GO:0016045	detection of bacterium	biological_process
GO:0032495	response to muramyl dipeptide	biological_process
GO:0032498	detection of muramyl dipeptide	biological_process
GO:0032731	positive regulation of interleukin-1 beta production	biological_process
GO:0032733	positive regulation of interleukin-10 production	biological_process
GO:0032740	positive regulation of interleukin-17 production	biological_process
GO:0032755	positive regulation of interleukin-6 production	biological_process
GO:0032760	positive regulation of tumor necrosis factor production	biological_process
GO:0032874	positive regulation of stress-activated MAPK cascade	biological_process
GO:0034130	toll-like receptor 1 signaling pathway	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	biological_process
GO:0034138	toll-like receptor 3 signaling pathway	biological_process
GO:0034142	toll-like receptor 4 signaling pathway	biological_process
GO:0035419	activation of MAPK activity involved in innate immune response	biological_process
GO:0035556	intracellular signal transduction	biological_process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological_process
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological_process
GO:0042742	defense response to bacterium	biological_process
GO:0042981	regulation of apoptotic process	biological_process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological_process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	biological_process
GO:0045087	innate immune response	biological_process
GO:0045747	positive regulation of Notch signaling pathway	biological_process
GO:0046330	positive regulation of JNK cascade	biological_process
GO:0046645	positive regulation of gamma-delta T cell activation	biological_process
GO:0050679	positive regulation of epithelial cell proliferation	biological_process
GO:0050718	positive regulation of interleukin-1 beta secretion	biological_process
GO:0050727	regulation of inflammatory response	biological_process
GO:0050871	positive regulation of B cell activation	biological_process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological_process
GO:0051259	protein oligomerization	biological_process
GO:0051353	positive regulation of oxidoreductase activity	biological_process
GO:0051403	stress-activated MAPK cascade	biological_process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	biological_process
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	biological_process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological_process
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	biological_process
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	biological_process
GO:2000110	negative regulation of macrophage apoptosis	biological_process
GO:2000363	positive regulation of prostaglandin-E synthase activity	biological_process
GO:0005622	intracellular	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0008180	signalosome	cellular_component
GO:0009986	cell surface	cellular_component
GO:0031982	vesicle	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005524	ATP binding	molecular_function
GO:0019899	enzyme binding	molecular_function
GO:0019901	protein kinase binding	molecular_function
GO:0032500	muramyl dipeptide binding	molecular_function
GO:0042834	peptidoglycan binding	molecular_function
GO:0050700	CARD domain binding	molecular_function
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