ryanodine receptor 2 (cardiac)

Symbol

RYR2 (may also be known as: None)

Organism

Human

Description

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Ryr2 Mus musculus
Ryr2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2634 Hypermethylation of RYR2 is positively correlated with age Molecular blood Human RYR2 —

GO Terms

GO IDGO TermGO Category
GO:0001666 response to hypoxia biological_process
GO:0003143 embryonic heart tube morphogenesis biological_process
GO:0005513 detection of calcium ion biological_process
GO:0006811 ion transport biological_process
GO:0006816 calcium ion transport biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008627 induction of apoptosis by ionic changes biological_process
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion biological_process
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum biological_process
GO:0019722 calcium-mediated signaling biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0031000 response to caffeine biological_process
GO:0051209 release of sequestered calcium ion into cytosol biological_process
GO:0051480 cytosolic calcium ion homeostasis biological_process
GO:0051775 response to redox state biological_process
GO:0055085 transmembrane transport biological_process
GO:0060048 cardiac muscle contraction biological_process
GO:0060070 canonical Wnt receptor signaling pathway biological_process
GO:0060402 calcium ion transport into cytosol biological_process
GO:0070296 sarcoplasmic reticulum calcium ion transport biological_process
GO:0070588 calcium ion transmembrane transport biological_process
GO:0071313 cellular response to caffeine biological_process
GO:0001950 plasma membrane enriched fraction cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016529 sarcoplasmic reticulum cellular_component
GO:0030018 Z disc cellular_component
GO:0033017 sarcoplasmic reticulum membrane cellular_component
GO:0034704 calcium channel complex cellular_component
GO:0004872 receptor activity molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005218 intracellular ligand-gated calcium channel activity molecular_function
GO:0005219 ryanodine-sensitive calcium-release channel activity molecular_function
GO:0005262 calcium channel activity molecular_function
GO:0005509 calcium ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005516 calmodulin binding molecular_function
GO:0015278 calcium-release channel activity molecular_function
GO:0034236 protein kinase A catalytic subunit binding molecular_function
GO:0034237 protein kinase A regulatory subunit binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0043924 suramin binding molecular_function