ryanodine receptor 2 (cardiac)

Symbol

RYR2 (may also be known as: None)

Organism

Human

Description

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
Ryr2	Mus musculus
Ryr2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2634	Hypermethylation of RYR2 is positively correlated with age	Molecular	blood	Human	RYR2	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001666	response to hypoxia	biological_process
GO:0003143	embryonic heart tube morphogenesis	biological_process
GO:0005513	detection of calcium ion	biological_process
GO:0006811	ion transport	biological_process
GO:0006816	calcium ion transport	biological_process
GO:0006874	cellular calcium ion homeostasis	biological_process
GO:0007275	multicellular organismal development	biological_process
GO:0008627	induction of apoptosis by ionic changes	biological_process
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	biological_process
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological_process
GO:0019722	calcium-mediated signaling	biological_process
GO:0030509	BMP signaling pathway	biological_process
GO:0031000	response to caffeine	biological_process
GO:0051209	release of sequestered calcium ion into cytosol	biological_process
GO:0051480	cytosolic calcium ion homeostasis	biological_process
GO:0051775	response to redox state	biological_process
GO:0055085	transmembrane transport	biological_process
GO:0060048	cardiac muscle contraction	biological_process
GO:0060070	canonical Wnt receptor signaling pathway	biological_process
GO:0060402	calcium ion transport into cytosol	biological_process
GO:0070296	sarcoplasmic reticulum calcium ion transport	biological_process
GO:0070588	calcium ion transmembrane transport	biological_process
GO:0071313	cellular response to caffeine	biological_process
GO:0001950	plasma membrane enriched fraction	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0016020	membrane	cellular_component
GO:0016021	integral to membrane	cellular_component
GO:0016529	sarcoplasmic reticulum	cellular_component
GO:0030018	Z disc	cellular_component
GO:0033017	sarcoplasmic reticulum membrane	cellular_component
GO:0034704	calcium channel complex	cellular_component
GO:0004872	receptor activity	molecular_function
GO:0005216	ion channel activity	molecular_function
GO:0005218	intracellular ligand-gated calcium channel activity	molecular_function
GO:0005219	ryanodine-sensitive calcium-release channel activity	molecular_function
GO:0005262	calcium channel activity	molecular_function
GO:0005509	calcium ion binding	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005516	calmodulin binding	molecular_function
GO:0015278	calcium-release channel activity	molecular_function
GO:0034236	protein kinase A catalytic subunit binding	molecular_function
GO:0034237	protein kinase A regulatory subunit binding	molecular_function
GO:0042802	identical protein binding	molecular_function
GO:0043924	suramin binding	molecular_function
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