proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

Symbol

PSME1 (may also be known as: None)

Organism

Human

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Orthologs

SymbolSpecies
psme1 Danio rerio
Psme1 Mus musculus
Psme1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2758 Hypomethylation of PSME1 is positively correlated with age Molecular blood Human PSME1 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1813 proteasome (prosome, macropain) 28 subunit, alpha Molecular muscle Mouse Psme1 4.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0000084 S phase of mitotic cell cycle biological_process
GO:0000209 protein polyubiquitination biological_process
GO:0000216 M/G1 transition of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent biological_process
GO:0006521 regulation of cellular amino acid metabolic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest biological_process
GO:0010467 gene expression biological_process
GO:0016032 viral reproduction biological_process
GO:0016070 RNA metabolic process biological_process
GO:0016071 mRNA metabolic process biological_process
GO:0019884 antigen processing and presentation of exogenous antigen biological_process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0000502 proteasome complex cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0008537 proteasome activator complex cellular_component
GO:0061133 endopeptidase activator activity molecular_function