T-box 20

Symbol

TBX20 (may also be known as: None)

Organism

Human

Description

This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Orthologs

SymbolSpecies
mid Drosophila melanogaster
tbx20 Danio rerio
Tbx20 Mus musculus
Tbx20 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2773 Hypermethylation of TBX20 is positively correlated with age Molecular blood Human TBX20 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001569 patterning of blood vessels biological_process
GO:0001706 endoderm formation biological_process
GO:0001764 neuron migration biological_process
GO:0001947 heart looping biological_process
GO:0003148 outflow tract septum morphogenesis biological_process
GO:0003175 tricuspid valve development biological_process
GO:0003180 aortic valve morphogenesis biological_process
GO:0003193 pulmonary valve formation biological_process
GO:0003207 cardiac chamber formation biological_process
GO:0003215 cardiac right ventricle morphogenesis biological_process
GO:0003272 endocardial cushion formation biological_process
GO:0003279 cardiac septum development biological_process
GO:0006936 muscle contraction biological_process
GO:0008015 blood circulation biological_process
GO:0008283 cell proliferation biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0010991 negative regulation of SMAD protein complex assembly biological_process
GO:0021524 visceral motor neuron differentiation biological_process
GO:0035050 embryonic heart tube development biological_process
GO:0035922 foramen ovale closure biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048370 lateral mesoderm formation biological_process
GO:0055008 cardiac muscle tissue morphogenesis biological_process
GO:0060413 atrial septum morphogenesis biological_process
GO:0060577 pulmonary vein morphogenesis biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function
GO:0001085 RNA polymerase II transcription factor binding molecular_function
GO:0001102 RNA polymerase II activating transcription factor binding molecular_function
GO:0001105 RNA polymerase II transcription coactivator activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function