T-box 20

Symbol

TBX20 (may also be known as: None)

Organism

Human

Description

This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Orthologs

Symbol	Species
mid	Drosophila melanogaster
tbx20	Danio rerio
Tbx20	Mus musculus
Tbx20	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2773	Hypermethylation of TBX20 is positively correlated with age	Molecular	blood	Human	TBX20	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0001569	patterning of blood vessels	biological_process
GO:0001706	endoderm formation	biological_process
GO:0001764	neuron migration	biological_process
GO:0001947	heart looping	biological_process
GO:0003148	outflow tract septum morphogenesis	biological_process
GO:0003175	tricuspid valve development	biological_process
GO:0003180	aortic valve morphogenesis	biological_process
GO:0003193	pulmonary valve formation	biological_process
GO:0003207	cardiac chamber formation	biological_process
GO:0003215	cardiac right ventricle morphogenesis	biological_process
GO:0003272	endocardial cushion formation	biological_process
GO:0003279	cardiac septum development	biological_process
GO:0006936	muscle contraction	biological_process
GO:0008015	blood circulation	biological_process
GO:0008283	cell proliferation	biological_process
GO:0009953	dorsal/ventral pattern formation	biological_process
GO:0010991	negative regulation of SMAD protein complex assembly	biological_process
GO:0021524	visceral motor neuron differentiation	biological_process
GO:0035050	embryonic heart tube development	biological_process
GO:0035922	foramen ovale closure	biological_process
GO:0045892	negative regulation of transcription, DNA-dependent	biological_process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_process
GO:0048370	lateral mesoderm formation	biological_process
GO:0055008	cardiac muscle tissue morphogenesis	biological_process
GO:0060413	atrial septum morphogenesis	biological_process
GO:0060577	pulmonary vein morphogenesis	biological_process
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function
GO:0001085	RNA polymerase II transcription factor binding	molecular_function
GO:0001102	RNA polymerase II activating transcription factor binding	molecular_function
GO:0001105	RNA polymerase II transcription coactivator activity	molecular_function
GO:0003677	DNA binding	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular_function
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