myosin IIIA

Symbol

MYO3A (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ninaC Drosophila melanogaster
myo3a Danio rerio
Myo3a Mus musculus
Myo3a Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0007601 visual perception biological_process
GO:0007605 sensory perception of sound biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0050896 response to stimulus biological_process
GO:0005737 cytoplasm cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0016459 myosin complex cellular_component
GO:0030175 filopodium cellular_component
GO:0031941 filamentous actin cellular_component
GO:0000146 microfilament motor activity molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0003774 motor activity molecular_function
GO:0003779 actin binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005516 calmodulin binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0030898 actin-dependent ATPase activity molecular_function
GO:0043531 ADP binding molecular_function
GO:0060002 plus-end directed microfilament motor activity molecular_function