phosphodiesterase 4C, cAMP-specific
Symbol
PDE4C
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA3314 | Gene expression of PDE4C increases with age | Molecular | skin | Human | PDE4C | — | |
| DAA2751 | Hypermethylation of PDE4C is positively correlated with age | Molecular | blood | Human | PDE4C | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006198 | cAMP catabolic process | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0046676 | negative regulation of insulin secretion | biological_process | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0072372 | primary cilium | cellular_component | |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | molecular_function | |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | molecular_function | |
| GO:0008081 | phosphoric diester hydrolase activity | molecular_function | |
| GO:0008144 | drug binding | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |