mitogen-activated protein kinase kinase kinase 5
Symbol
Organism
Description
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Pk92B | Drosophila melanogaster | |
| map3k5 | Danio rerio | |
| Map3k5 | Mus musculus | |
| Map3k5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2648 | Hypomethylation of MAP3K5 is positively correlated with age | Molecular | blood | Human | MAP3K5 | — | |
| DAA2737 | Hypomethylation of MAP3K5 is positively correlated with age | Molecular | blood | Human | MAP3K5 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000165 | MAPKKK cascade | biological_process | |
| GO:0000186 | activation of MAPKK activity | biological_process | |
| GO:0000187 | activation of MAPK activity | biological_process | |
| GO:0006919 | activation of caspase activity | biological_process | |
| GO:0006950 | response to stress | biological_process | |
| GO:0007254 | JNK cascade | biological_process | |
| GO:0007257 | activation of JUN kinase activity | biological_process | |
| GO:0008624 | induction of apoptosis by extracellular signals | biological_process | |
| GO:0008631 | induction of apoptosis by oxidative stress | biological_process | |
| GO:0010421 | hydrogen peroxide-mediated programmed cell death | biological_process | |
| GO:0043065 | positive regulation of apoptotic process | biological_process | |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | biological_process | |
| GO:0044419 | interspecies interaction between organisms | biological_process | |
| GO:0045087 | innate immune response | biological_process | |
| GO:0070301 | cellular response to hydrogen peroxide | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0000287 | magnesium ion binding | molecular_function | |
| GO:0004672 | protein kinase activity | molecular_function | |
| GO:0004674 | protein serine/threonine kinase activity | molecular_function | |
| GO:0004709 | MAP kinase kinase kinase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | molecular_function | |
| GO:0019901 | protein kinase binding | molecular_function | |
| GO:0019903 | protein phosphatase binding | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |