mitogen-activated protein kinase kinase kinase 5

Symbol

MAP3K5 (may also be known as: None)

Organism

Human

Description

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Pk92B Drosophila melanogaster
map3k5 Danio rerio
Map3k5 Mus musculus
Map3k5 Rattus norvegicus

Links to external resources

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0000186 activation of MAPKK activity biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0006919 activation of caspase activity biological_process
GO:0006950 response to stress biological_process
GO:0007254 JNK cascade biological_process
Show more GO terms