mitogen-activated protein kinase kinase kinase 5

Symbol

MAP3K5 (may also be known as: None)

Organism

Human

Description

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
Pk92B	Drosophila melanogaster
map3k5	Danio rerio
Map3k5	Mus musculus
Map3k5	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2648	Hypomethylation of MAP3K5 is positively correlated with age	Molecular	blood	Human	MAP3K5	—
DAA2737	Hypomethylation of MAP3K5 is positively correlated with age	Molecular	blood	Human	MAP3K5	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000165	MAPKKK cascade	biological_process
GO:0000186	activation of MAPKK activity	biological_process
GO:0000187	activation of MAPK activity	biological_process
GO:0006919	activation of caspase activity	biological_process
GO:0006950	response to stress	biological_process
GO:0007254	JNK cascade	biological_process
GO:0007257	activation of JUN kinase activity	biological_process
GO:0008624	induction of apoptosis by extracellular signals	biological_process
GO:0008631	induction of apoptosis by oxidative stress	biological_process
GO:0010421	hydrogen peroxide-mediated programmed cell death	biological_process
GO:0043065	positive regulation of apoptotic process	biological_process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process
GO:0044419	interspecies interaction between organisms	biological_process
GO:0045087	innate immune response	biological_process
GO:0070301	cellular response to hydrogen peroxide	biological_process
GO:0005737	cytoplasm	cellular_component
GO:0005783	endoplasmic reticulum	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0000287	magnesium ion binding	molecular_function
GO:0004672	protein kinase activity	molecular_function
GO:0004674	protein serine/threonine kinase activity	molecular_function
GO:0004709	MAP kinase kinase kinase activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005524	ATP binding	molecular_function
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	molecular_function
GO:0019901	protein kinase binding	molecular_function
GO:0019903	protein phosphatase binding	molecular_function
GO:0042803	protein homodimerization activity	molecular_function
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