lymphocyte-activation gene 3
Symbol
LAG3
(may also be known as: None)
Organism
Human
Description
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Lag3 | Mus musculus | |
| Lag3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2656 | Hypomethylation of LAG3 is positively correlated with age | Molecular | blood | Human | LAG3 | — | |
| DAA2733 | Hypomethylation of LAG3 is positively correlated with age | Molecular | blood | Human | LAG3 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007166 | cell surface receptor linked signaling pathway | biological_process | |
| GO:0045085 | negative regulation of interleukin-2 biosynthetic process | biological_process | |
| GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | biological_process | |
| GO:0050868 | negative regulation of T cell activation | biological_process | |
| GO:0009897 | external side of plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0003823 | antigen binding | molecular_function | |
| GO:0004888 | transmembrane signaling receptor activity | molecular_function | |
| GO:0042289 | MHC class II protein binding | molecular_function | |