integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Symbol
ITGA2B
(may also be known as: None)
Organism
Human
Description
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| pat-2 | Caenorhabditis elegans | |
| if | Drosophila melanogaster | |
| Itga2b | Mus musculus | |
| Itga2b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002576 | platelet degranulation | biological_process | |
| GO:0007155 | cell adhesion | biological_process | |
| GO:0007160 | cell-matrix adhesion | biological_process | |
| GO:0007229 | integrin-mediated signaling pathway | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0030168 | platelet activation | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0005925 | focal adhesion | cellular_component | |
| GO:0008305 | integrin complex | cellular_component | |
| GO:0009897 | external side of plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031092 | platelet alpha granule membrane | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0042802 | identical protein binding | molecular_function | |
| GO:0050840 | extracellular matrix binding | molecular_function | |