integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

Symbol

ITGA2B (may also be known as: None)

Organism

Human

Description

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
pat-2 Caenorhabditis elegans
if Drosophila melanogaster
Itga2b Mus musculus
Itga2b Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0002576 platelet degranulation biological_process
GO:0007155 cell adhesion biological_process
GO:0007160 cell-matrix adhesion biological_process
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007411 axon guidance biological_process
GO:0007596 blood coagulation biological_process
Show more GO terms