homeobox B8
Symbol
HOXB8
(may also be known as: None)
Organism
Human
Description
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Antp | Drosophila melanogaster | |
| hoxb8a | Danio rerio | |
| Hoxb8 | Mus musculus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007625 | grooming behavior | biological_process | |
| GO:0008344 | adult locomotory behavior | biological_process | |
| GO:0009952 | anterior/posterior pattern specification | biological_process | |
| GO:0019233 | sensory perception of pain | biological_process | |
| GO:0021516 | dorsal spinal cord development | biological_process | |
| GO:0048704 | embryonic skeletal system morphogenesis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |