homeobox B6

Symbol

HOXB6 (may also be known as: None)

Organism

Human

Description

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
hoxb6b Danio rerio
Hoxb6 Mus musculus
Hoxb6 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008595 anterior/posterior axis specification, embryo biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0034101 erythrocyte homeostasis biological_process
GO:0048704 embryonic skeletal system morphogenesis biological_process
GO:0005634 nucleus cellular_component
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function