homeobox B6
Symbol
HOXB6
(may also be known as: None)
Organism
Human
Description
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| hoxb6b | Danio rerio | |
| Hoxb6 | Mus musculus | |
| Hoxb6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0008595 | anterior/posterior axis specification, embryo | biological_process | |
| GO:0009952 | anterior/posterior pattern specification | biological_process | |
| GO:0034101 | erythrocyte homeostasis | biological_process | |
| GO:0048704 | embryonic skeletal system morphogenesis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |