homeobox B5
Symbol
HOXB5
(may also be known as: None)
Organism
Human
Description
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| hoxb5b | Danio rerio | |
| Hoxb5 | Mus musculus | |
| Hoxb5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0009653 | anatomical structure morphogenesis | biological_process | |
| GO:0009952 | anterior/posterior pattern specification | biological_process | |
| GO:0045446 | endothelial cell differentiation | biological_process | |
| GO:0048704 | embryonic skeletal system morphogenesis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |