glycine receptor, alpha 1

Symbol

GLRA1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Orthologs

SymbolSpecies
glra1 Danio rerio
Glra1 Mus musculus
Glra1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2720 Hypermethylation of GLRA1 is positively correlated with age Molecular blood Human GLRA1 —

GO Terms

GO IDGO TermGO Category
GO:0001508 regulation of action potential biological_process
GO:0001964 startle response biological_process
GO:0002087 regulation of respiratory gaseous exchange by neurological system process biological_process
GO:0006811 ion transport biological_process
GO:0006821 chloride transport biological_process
GO:0006936 muscle contraction biological_process
GO:0007218 neuropeptide signaling pathway biological_process
GO:0007268 synaptic transmission biological_process
GO:0007601 visual perception biological_process
GO:0007628 adult walking behavior biological_process
GO:0034220 ion transmembrane transport biological_process
GO:0042391 regulation of membrane potential biological_process
GO:0043576 regulation of respiratory gaseous exchange biological_process
GO:0050884 neuromuscular process controlling posture biological_process
GO:0051970 negative regulation of transmission of nerve impulse biological_process
GO:0055085 transmembrane transport biological_process
GO:0060012 synaptic transmission, glycinergic biological_process
GO:0060013 righting reflex biological_process
GO:0060080 regulation of inhibitory postsynaptic membrane potential biological_process
GO:2000344 positive regulation of acrosome reaction biological_process
GO:0005622 intracellular cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030054 cell junction cellular_component
GO:0034707 chloride channel complex cellular_component
GO:0043231 intracellular membrane-bounded organelle cellular_component
GO:0045202 synapse cellular_component
GO:0045211 postsynaptic membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005230 extracellular ligand-gated ion channel activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016594 glycine binding molecular_function
GO:0016934 extracellular-glycine-gated chloride channel activity molecular_function
GO:0022824 transmitter-gated ion channel activity molecular_function
GO:0030977 taurine binding molecular_function