glycine receptor, alpha 1

Symbol

GLRA1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Orthologs

Symbol	Species
glra1	Danio rerio
Glra1	Mus musculus
Glra1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2720	Hypermethylation of GLRA1 is positively correlated with age	Molecular	blood	Human	GLRA1	—

First
Last

GO Terms

GO ID	GO Term	GO Category
GO:0001508	regulation of action potential	biological_process
GO:0001964	startle response	biological_process
GO:0002087	regulation of respiratory gaseous exchange by neurological system process	biological_process
GO:0006811	ion transport	biological_process
GO:0006821	chloride transport	biological_process
GO:0006936	muscle contraction	biological_process
GO:0007218	neuropeptide signaling pathway	biological_process
GO:0007268	synaptic transmission	biological_process
GO:0007601	visual perception	biological_process
GO:0007628	adult walking behavior	biological_process
GO:0034220	ion transmembrane transport	biological_process
GO:0042391	regulation of membrane potential	biological_process
GO:0043576	regulation of respiratory gaseous exchange	biological_process
GO:0050884	neuromuscular process controlling posture	biological_process
GO:0051970	negative regulation of transmission of nerve impulse	biological_process
GO:0055085	transmembrane transport	biological_process
GO:0060012	synaptic transmission, glycinergic	biological_process
GO:0060013	righting reflex	biological_process
GO:0060080	regulation of inhibitory postsynaptic membrane potential	biological_process
GO:2000344	positive regulation of acrosome reaction	biological_process
GO:0005622	intracellular	cellular_component
GO:0005624	membrane fraction	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0005887	integral to plasma membrane	cellular_component
GO:0009897	external side of plasma membrane	cellular_component
GO:0016021	integral to membrane	cellular_component
GO:0030054	cell junction	cellular_component
GO:0034707	chloride channel complex	cellular_component
GO:0043231	intracellular membrane-bounded organelle	cellular_component
GO:0045202	synapse	cellular_component
GO:0045211	postsynaptic membrane	cellular_component
GO:0004872	receptor activity	molecular_function
GO:0005216	ion channel activity	molecular_function
GO:0005230	extracellular ligand-gated ion channel activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0016594	glycine binding	molecular_function
GO:0016934	extracellular-glycine-gated chloride channel activity	molecular_function
GO:0022824	transmitter-gated ion channel activity	molecular_function
GO:0030977	taurine binding	molecular_function
▼ Show more GO terms