forkhead box P1

Symbol

FOXP1 (may also be known as: None)

Organism

Human

Description

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CHES-1-like Drosophila melanogaster
foxp1b Danio rerio
Foxp1 Mus musculus
Foxp1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2620 Hypomethylation of FOXP1 is positively correlated with age Molecular blood Human FOXP1 —

GO Terms

GO IDGO TermGO Category
GO:0001701 in utero embryonic development biological_process
GO:0002053 positive regulation of mesenchymal cell proliferation biological_process
GO:0002329 pre-B cell differentiation biological_process
GO:0002639 positive regulation of immunoglobulin production biological_process
GO:0007389 pattern specification process biological_process
GO:0007507 heart development biological_process
GO:0007519 skeletal muscle tissue development biological_process
GO:0008045 motor axon guidance biological_process
GO:0009790 embryo development biological_process
GO:0021517 ventral spinal cord development biological_process
GO:0030324 lung development biological_process
GO:0033152 immunoglobulin V(D)J recombination biological_process
GO:0045214 sarcomere organization biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048745 smooth muscle tissue development biological_process
GO:0050679 positive regulation of epithelial cell proliferation biological_process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0055007 cardiac muscle cell differentiation biological_process
GO:0060043 regulation of cardiac muscle cell proliferation biological_process
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis biological_process
GO:2000727 positive regulation of cardiac muscle cell differentiation biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0008301 DNA binding, bending molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function