forkhead box P1

Symbol

FOXP1 (may also be known as: None)

Organism

Human

Description

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
CHES-1-like	Drosophila melanogaster
foxp1b	Danio rerio
Foxp1	Mus musculus
Foxp1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2620	Hypomethylation of FOXP1 is positively correlated with age	Molecular	blood	Human	FOXP1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001701	in utero embryonic development	biological_process
GO:0002053	positive regulation of mesenchymal cell proliferation	biological_process
GO:0002329	pre-B cell differentiation	biological_process
GO:0002639	positive regulation of immunoglobulin production	biological_process
GO:0007389	pattern specification process	biological_process
GO:0007507	heart development	biological_process
GO:0007519	skeletal muscle tissue development	biological_process
GO:0008045	motor axon guidance	biological_process
GO:0009790	embryo development	biological_process
GO:0021517	ventral spinal cord development	biological_process
GO:0030324	lung development	biological_process
GO:0033152	immunoglobulin V(D)J recombination	biological_process
GO:0045214	sarcomere organization	biological_process
GO:0045892	negative regulation of transcription, DNA-dependent	biological_process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_process
GO:0048745	smooth muscle tissue development	biological_process
GO:0050679	positive regulation of epithelial cell proliferation	biological_process
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	biological_process
GO:0055007	cardiac muscle cell differentiation	biological_process
GO:0060043	regulation of cardiac muscle cell proliferation	biological_process
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	biological_process
GO:2000727	positive regulation of cardiac muscle cell differentiation	biological_process
GO:0005622	intracellular	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005667	transcription factor complex	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0003677	DNA binding	molecular_function
GO:0003682	chromatin binding	molecular_function
GO:0003690	double-stranded DNA binding	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular_function
GO:0003705	sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	molecular_function
GO:0008134	transcription factor binding	molecular_function
GO:0008270	zinc ion binding	molecular_function
GO:0008301	DNA binding, bending	molecular_function
GO:0042803	protein homodimerization activity	molecular_function
GO:0043565	sequence-specific DNA binding	molecular_function
GO:0046872	metal ion binding	molecular_function
GO:0046982	protein heterodimerization activity	molecular_function
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