ATP-binding cassette, sub-family A (ABC1), member 5
Symbol
Organism
Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| abca5 | Danio rerio | |
| Abca5 | Mus musculus | |
| Abca5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006810 | transport | biological_process | |
| GO:0010745 | negative regulation of macrophage derived foam cell differentiation | biological_process | |
| GO:0033344 | cholesterol efflux | biological_process | |
| GO:0034375 | high-density lipoprotein particle remodeling | biological_process | |
| GO:0043691 | reverse cholesterol transport | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005764 | lysosome | cellular_component | |
| GO:0005765 | lysosomal membrane | cellular_component | |
| GO:0005770 | late endosome | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031902 | late endosome membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016887 | ATPase activity | molecular_function | |