fibroblast growth factor 8 (androgen-induced)
Symbol
Organism
Description
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| fgf8b | Danio rerio | |
| Fgf8 | Mus musculus | |
| Fgf8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001656 | metanephros development | biological_process | |
| GO:0001823 | mesonephros development | biological_process | |
| GO:0003148 | outflow tract septum morphogenesis | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007369 | gastrulation | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0008286 | insulin receptor signaling pathway | biological_process | |
| GO:0008406 | gonad development | biological_process | |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | biological_process | |
| GO:0009653 | anatomical structure morphogenesis | biological_process | |
| GO:0042476 | odontogenesis | biological_process | |
| GO:0051781 | positive regulation of cell division | biological_process | |
| GO:0055026 | negative regulation of cardiac muscle tissue development | biological_process | |
| GO:0060348 | bone development | biological_process | |
| GO:0060563 | neuroepithelial cell differentiation | biological_process | |
| GO:0071542 | dopaminergic neuron differentiation | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0004713 | protein tyrosine kinase activity | molecular_function | |
| GO:0005105 | type 1 fibroblast growth factor receptor binding | molecular_function | |
| GO:0005111 | type 2 fibroblast growth factor receptor binding | molecular_function | |
| GO:0008083 | growth factor activity | molecular_function | |