fibroblast growth factor 8 (androgen-induced)

Symbol

FGF8 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
fgf8b Danio rerio
Fgf8 Mus musculus
Fgf8 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001656 metanephros development biological_process
GO:0001823 mesonephros development biological_process
GO:0003148 outflow tract septum morphogenesis biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007369 gastrulation biological_process
GO:0008284 positive regulation of cell proliferation biological_process
Show more GO terms