farnesyl-diphosphate farnesyltransferase 1

Symbol

FDFT1 (may also be known as: None)

Organism

Human

Description

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
si:ch73-107c13.2 Danio rerio
Fdft1 Mus musculus
Fdft1 Rattus norvegicus
ERG9 Saccharomyces cerevisiae
erg9 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3134 Gene expression of FDFT1 decreases with age Molecular skin Human FDFT1 —

GO Terms

GO IDGO TermGO Category
GO:0006694 steroid biosynthetic process biological_process
GO:0006695 cholesterol biosynthetic process biological_process
GO:0008299 isoprenoid biosynthetic process biological_process
GO:0008610 lipid biosynthetic process biological_process
GO:0009058 biosynthetic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045338 farnesyl diphosphate metabolic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004310 farnesyl-diphosphate farnesyltransferase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups molecular_function
GO:0051996 squalene synthase activity molecular_function