epoxide hydrolase 2, cytoplasmic

Symbol

EPHX2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Orthologs

SymbolSpecies
ephx2 Danio rerio
Ephx2 Mus musculus
Ephx2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2635 Hypomethylation of EPHX2 is positively correlated with age Molecular blood Human EPHX2 —

GO Terms

GO IDGO TermGO Category
GO:0006805 xenobiotic metabolic process biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0006954 inflammatory response biological_process
GO:0008152 metabolic process biological_process
GO:0008217 regulation of blood pressure biological_process
GO:0009636 response to toxin biological_process
GO:0017144 drug metabolic process biological_process
GO:0019439 aromatic compound catabolic process biological_process
GO:0045909 positive regulation of vasodilation biological_process
GO:0072593 reactive oxygen species metabolic process biological_process
GO:0005625 soluble fraction cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005777 peroxisome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005829 cytosol cellular_component
GO:0005925 focal adhesion cellular_component
GO:0003824 catalytic activity molecular_function
GO:0004301 epoxide hydrolase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0046872 metal ion binding molecular_function